Predictors and outcomes of acute, sub-acute and early stroke following transcatheter aortic valve implantation

Abstract Background Stroke is one of the most devastating complications after transcatheter aortic valve implantation (TAVI). The recent third Valve Academic Research Consortium (VARC-3) proposes new stroke terminology according to time between TAVI and onset. Purpose We aimed identify predictors assessed mortality in patients undergoing transfemoral complicated by acute, sub-acute early stroke. Methods Patients were included a global patient level database. Acute was defined as occurring ≤24 hours index procedure. Sub-acute >1 day ≤30 days >30 ≤365 following TAVI, VARC-3. identified for these using multivariate logistic regression analysis outcomes patients. Results A total 11230 underwent TAVI. Mean age 81.5±7.0 years, 58% female median STS-PROM score 6.5% (4.0%-13.2%). 405 (3.6%) experienced during first year Of 93 (23%) had acute stroke, 195 (46%) 117 (27%) One highest (56.9%), followed (41.7%), (29.0%), but one-year all higher than non-stroke (40.5% vs 15.8%, p<0.001). Glomerular filtration rate an independent predictor (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.9–1.0, p=0.03). Previous cerebrovascular events independently predicted (OR 2.1, CI 1.4–3.1, p=0.001). Independent 1.0 per year, 1.0–1.0, p=0.04) peripheral vascular disease 2.0, 1.4–3.0, Conclusions showed Earlier timing post-TAVI associated with increased mortality. renal impairment; previous disease, suggesting different pathways leading Funding Acknowledgement Type funding sources: Foundation. Main source(s): Hartstichting